Welcome to the European Conditional Mouse Mutagenesis Program
About EUCOMM
The EUCOMM Integrated Project is funded by the European Union Framework 6 programme.
The goal of EUCOMM is to generate a collection of up to 13,000 mutated genes in mouse C57BL/6N embryonic stem (ES) cells using conditional gene trapping and gene targeting approaches.
This library will enable mouse mutants to be established worldwide in a standardized and cost-effective manner, making mouse mutants available to a much wider biomedical research community than has been possible previously. More
We would also like to invite the scientific community to help prioritize the genes for targeted mutagenesis in ES cells by emailing us at eucomm@sanger.ac.uk.
Latest News & Events
26 October – 8 November 2009
EUCOMM Training Event - Genetic Manipulation of ES Cells
This course took place in November 2009 and provided a comprehensive overview and practical laboratory experience of the genetic manipulation of ES cells for a broad range of applications. Attendees were in the main postdoctoral scientists and senior PhD students actively engaged in research. The course covered a range of topics including recent advances in genome informatics, BAC recombineering, transposon technology and conditional gene targeting. More
Disclaimer
The EUCOMM resource is a high-throughput gene targeting effort, and for practical reasons, all clones have been characterized by PCR only. In a random sampling of the resource, Southern blot analysis revealed complex events in approximately 15% of the ES cell clones. Thus, we highly recommend that individual investigators use Southern blot analysis to verify correct targeting of the gene for all clones obtained from the EUCOMM resource.