European Conditional Mouse Mutagenesis Program

Publications Relating to the EUCOMM Project

2010

  • A Conditional Knockout Resource for Genome-Wide Analysis of Mouse Gene Function.
    Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Cox T, Jackson D, Severin J, Biggs P, Thomas M, Mujica A, Harrow J, Fu J, Nefedov M, de Jong P, Stewart AF, Bradley A
    Nature 2010 (submitted)
  • EuroPhenome: a repository for high-throughput mouse phenotyping data.
    Morgan H, Beck T, Blake A, Gates H, Adams N, Debouzy G, Leblanc S, Lengger C, Maier H, Melvin D, Meziane H, Richardson D, Wells S, White J, Wood J, The EUMODIC Consortium, de Angelis MH, Brown SD, Hancock JM, Mallon AM
    Nucleic Acids Res. 2009;. PMID: 19933761 DOI: 10.1093/nar/gkp1007
  • EMMA--mouse mutant resources for the international scientific community.
    Wilkinson P, Sengerova J, Matteoni R, Chen CK, Soulat G, Ureta-Vidal A, Fessele S, Hagn M, Massimi M, Pickford K, Butler RH, Marschall S, Mallon AM, Pickard A, Raspa M, Scavizzi F, Fray M, Larrigaldie V, Leyritz J, Birney E, Tocchini-Valentini GP, Brown S, Herault Y, Montoliu L, de Angelis MH, Smedley D
    Nucleic Acids Res. 2010;38;D570-6. PMID: 19783817 DOI: 10.1093/nar/gkp799
  • MouseBook: an integrated portal of mouse resources.
    Blake A, Pickford K, Greenaway S, Thomas S, Pickard A, Williamson CM, Adams NC, Walling A, Beck T, Fray M, Peters J, Weaver T, Brown SD, Hancock JM, Mallon AM
    Nucleic Acids Res. 2010;38;D593-9. PMID: 19854936 DOI: 10.1093/nar/gkp867
  • Floxin, a resource for genetically engineering mouse ESCs.
    Singla V, Hunkapiller J, Santos N, Seol AD, Norman AR, Wakenight P, Skarnes WC, Reiter JF
    Nat Methods. 2010;7;50-2. PMID: 19966808 DOI: 10.1038/nmeth.1406

2009

  • Agouti C57BL/6N embryonic stem cells for mouse genetic resources.
    Pettitt SJ, Liang Q, Rairdan XY, Moran JL, Prosser HM, Beier DR, Lloyd KC, Bradley A, Skarnes WC
    Nat Methods. 2009;. PMID: 19525957 DOI: 10.1038/nmeth.1342
  • Targeting embryonic stem cells.
    Friedel RH
    Methods Mol Biol. 2009;561;185-97. PMID: 19504072 DOI: 10.1007/978-1-60327-019-9_12
  • Chromosome Engineering in ES Cells.
    van der Weyden L, Shaw-Smith C, Bradley A
    Methods Mol Biol. 2009;530;1-29. PMID: 19266329 DOI: 10.1007/978-1-59745-471-1_4
  • Construction of gene-targeting vectors by recombineering.
    Lee SC, Wang W, Liu P
    Methods Mol Biol. 2009;530;1-13. PMID: 19266337 DOI: 10.1007/978-1-59745-471-1_2
  • Dre recombinase, like Cre, is a highly efficient site-specific recombinase in E. coli, mammalian cells and mice.
    Anastassiadis K, Fu J, Patsch C, Hu S, Weidlich S, Duerschke K, Buchholz F, Edenhofer F, Stewart AF
    Dis Model Mech. 2009 Sep-Oct ;2;508-15. PMID: 19692579 DOI: 10.1242/dmm.003087
  • Site-specific recombinases for manipulation of the mouse genome.
    Birling MC, Gofflot F, Warot X
    Methods Mol Biol. 2009;561;245-63. PMID: 19504076 DOI: 10.1007/978-1-60327-019-9_16
  • Overview on mouse mutagenesis.
    Kühn R, Wurst W
    Methods Mol Biol. 2009;530;1-12. PMID: 19266348 DOI: 10.1007/978-1-59745-471-1_1
  • The functional annotation of mammalian genomes: the challenge of phenotyping.
    Brown SD, Wurst W, Kühn R, Hancock JM
    Annu Rev Genet. 2009;43;305-33. PMID: 19689210 DOI: 10.1146/annurev-genet-102108-134143
  • Towards better mouse models: enhanced genotypes, systemic phenotyping and envirotype modelling.
    Beckers J, Wurst W, de Angelis MH
    Nat Rev Genet. 2009;. PMID: 19434078 DOI: 10.1038/nrg2578
  • PRIME importance of pathology expertise.
    Schofield PN, Brown SD, Sundberg JP, Arends M, Warren MV, Dubus P, Ellender M, Fiette L, Rozell B, Quintanilla-Martinez L, Raspa M, Song JY, van der Valk M, McKerlie C
    Nat Biotechnol. 2009;27;24-5. PMID: 19131991 DOI: 10.1038/nbt0109-24
  • Post-publication sharing of data and tools.
    Schofield PN, Bubela T, Weaver T, Portilla L, Brown SD, Hancock JM, Einhorn D, Tocchini-Valentini G, Hrabe de Angelis M, Rosenthal N, CASIMIR Rome Meeting participants
    Nature. 2009;461;171-3. PMID: 19741686 DOI: 10.1038/461171a
  • Gene-trap vectors and mutagenesis.
    De-Zolt S, Altschmied J, Ruiz P, von Melchner H, Schnütgen F
    Methods Mol Biol. 2009;530;29-47. PMID: 19266330 DOI: 10.1007/978-1-59745-471-1_3
  • Processing of multiple-intron-containing pretRNA.
    Tocchini-Valentini GD, Fruscoloni P, Tocchini-Valentini GP
    Proc Natl Acad Sci U S A. 2009;106;20246-51. PMID: 19910528 DOI: 10.1073/pnas.0911658106
  • Transposon-mediated genome manipulation in vertebrates.
    Ivics Z, Li MA, Mátés L, Boeke JD, Nagy A, Bradley A, Izsvák Z
    Nat Methods. 2009;6;415-22. PMID: 19478801 DOI: 10.1038/nmeth.1332
  • Chromosomal mobilization and reintegration of Sleeping Beauty and PiggyBac transposons.
    Liang Q, Kong J, Stalker J, Bradley A
    Genesis. 2009;. PMID: 19391106 DOI: 10.1002/dvg.20508
  • Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon.
    Yusa K, Rad R, Takeda J, Bradley A
    Nat Methods. 2009;. PMID: 19337237 DOI: 10.1038/nmeth.1323
  • A piggyBac transposon-based genome-wide library of insertionally mutated Blm-deficient murine ES cells.
    Wang W, Bradley A, Huang Y
    Genome Res. 2009;. PMID: 19233961 DOI: 10.1101/gr.085621.108
  • piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells.
    Woltjen K, Michael IP, Mohseni P, Desai R, Mileikovsky M, Hämäläinen R, Cowling R, Wang W, Liu P, Gertsenstein M, Kaji K, Sung HK, Nagy A
    Nature. 2009;. PMID: 19252478 DOI: 10.1038/nature07863
  • Identification of protein/DNA contacts with dimethyl sulfate: methylation protection and methylation interference.
    Shaw PE, Stewart AF
    Methods Mol Biol. 2009;543;97-104. PMID: 19378162 DOI: 10.1007/978-1-60327-015-1_8
  • Doxycycline-dependent photoactivated gene expression in eukaryotic systems.
    Cambridge SB, Geissler D, Calegari F, Anastassiadis K, Hasan MT, Stewart AF, Huttner WB, Hagen V, Bonhoeffer T
    Nat Methods. 2009;6;527-31. PMID: 19503080 DOI: 10.1038/nmeth.1340
  • A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice.
    Enard W, Gehre S, Hammerschmidt K, Hölter SM, Blass T, Somel M, Brückner MK, Schreiweis C, Winter C, Sohr R, Becker L, Wiebe V, Nickel B, Giger T, Müller U, Groszer M, Adler T, Aguilar A, Bolle I, Calzada-Wack J, Dalke C, Ehrhardt N, Favor J, Fuchs H, Gailus-Durner V, Hans W, Hölzlwimmer G, Javaheri A, Kalaydjiev S, Kallnik M, Kling E, Kunder S, Mossbrugger I, Naton B, Racz I, Rathkolb B, Rozman J, Schrewe A, Busch DH, Graw J, Ivandic B, Klingenspor M, Klopstock T, Ollert M, Quintanilla-Martinez L, Schulz H, Wolf E, Wurst W, Zimmer A, Fisher SE, Morgenstern R, Arendt T, de Angelis MH, Fischer J, Schwarz J, Pääbo S
    Cell. 2009;137;961-71. PMID: 19490899 DOI: 10.1016/j.cell.2009.03.041

2008

  • Enhanced gene trapping in mouse embryonic stem cells.
    Schnütgen F, Hansen J, De-Zolt S, Horn C, Lutz M, Floss T, Wurst W, Noppinger PR, von Melchner H
    Nucleic Acids Res. 2008;36;e133. PMID: 18812397 DOI: 10.1093/nar/gkn603
  • EUCOMM--the European conditional mouse mutagenesis program.
    Friedel RH, Seisenberger C, Kaloff C, Wurst W
    Brief Funct Genomic Proteomic. 2007;6;180-5. PMID: 17967808 DOI: 10.1093/bfgp/elm022
  • Novel caspase-suicide proteins for tamoxifen-inducible apoptosis.
    Chu Y, Senghaas N, Köster RW, Wurst W, Kühn R
    Genesis. 2008;46;530-6. PMID: 18802959 DOI: 10.1002/dvg.20426
  • Simultaneous Cre-mediated conditional knockdown of two genes in mice.
    Steuber-Buchberger P, Wurst W, Kühn R
    Genesis. 2008;46;144-51. PMID: 18327788 DOI: 10.1002/dvg.20376
  • Analysis of CRE-mediated recombination driven by myosin light chain 1/3 regulatory elements in embryonic and adult skeletal muscle: a tool to study fiber specification.
    Mourkioti F, Slonimsky E, Huth M, Berno V, Rosenthal N
    Genesis. 2008;46;424-30. PMID: 18693277 DOI: 10.1002/dvg.20419
  • Pleiotropic effects in Eya3 knockout mice.
    Soker T, Dalke C, Puk O, Floss T, Becker L, Bolle I, Favor J, Hans W, Hoelter SM, Horsch M, Kallnik M, Kling E, Morth C, Schrewe A, Stigloher C, Topp S, Gailus-Durner V, Naton B, Beckers J, Fuchs H, Ivandic B, Klopstock T, Schulz H, Wolf E, Wurst W, Bally-Cuif L, Hrabe de Angelis M, Graw J
    BMC Dev Biol. 2008;8;118. PMID: 19102749 DOI: 10.1186/1471-213X-8-118
  • Deletion of glucose transporter GLUT8 in mice increases locomotor activity.
    Schmidt S, Gawlik V, Hölter SM, Augustin R, Scheepers A, Behrens M, Wurst W, Gailus-Durner V, Fuchs H, Hrabé de Angelis M, Kluge R, Joost HG, Schürmann A
    Behav Genet. 2008;38;396-406. PMID: 18461434 DOI: 10.1007/s10519-008-9208-1
  • MausDB: an open source application for phenotype data and mouse colony management in large-scale mouse phenotyping projects.
    Maier H, Lengger C, Simic B, Fuchs H, Gailus-Durner V, Hrabé de Angelis M
    BMC Bioinformatics. 2008;9;169. PMID: 18366799 DOI: 10.1186/1471-2105-9-169
  • A DNA transposon-based approach to validate oncogenic mutations in the mouse.
    Su Q, Prosser HM, Campos LS, Ortiz M, Nakamura T, Warren M, Dupuy AJ, Jenkins NA, Copeland NG, Bradley A, Liu P
    Proc Natl Acad Sci U S A. 2008;105;19904-9. PMID: 19064922 DOI: 10.1073/pnas.0807785105
  • Chromosomal transposition of PiggyBac in mouse embryonic stem cells.
    Wang W, Lin C, Lu D, Ning Z, Cox T, Melvin D, Wang X, Bradley A, Liu P
    Proc Natl Acad Sci U S A. 2008;. PMID: 18579772 DOI: 10.1073/pnas.0801017105
  • Extensive genomic copy number variation in embryonic stem cells.
    Liang Q, Conte N, Skarnes WC, Bradley A
    Proc Natl Acad Sci U S A. 2008;105;17453-6. PMID: 18988746 DOI: 10.1073/pnas.0805638105
  • ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a.
    Gao X, Tate P, Hu P, Tjian R, Skarnes WC, Wang Z
    Proc Natl Acad Sci U S A. 2008;105;6656-61. PMID: 18448678 DOI: 10.1073/pnas.0801802105
  • Modeling insertional mutagenesis using gene length and expression in murine embryonic stem cells.
    Nord AS, Vranizan K, Tingley W, Zambon AC, Hanspers K, Fong LG, Hu Y, Bacchetti P, Ferrin TE, Babbitt PC, Doniger SW, Skarnes WC, Young SG, Conklin BR
    PLoS ONE. 2007;2;e617. PMID: 17637833 DOI: 10.1371/journal.pone.0000617

2007

  • Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity.
    Trivedi CM, Luo Y, Yin Z, Zhang M, Zhu W, Wang T, Floss T, Goettlicher M, Noppinger PR, Wurst W, Ferrari VA, Abrams CS, Gruber PJ, Epstein JA
    Nat Med. 2007;13;324-31. PMID: 17322895 DOI: 10.1038/nm1552
  • A mouse for all reasons.
    International Mouse Knockout Consortium, Collins FS, Rossant J, Wurst W
    Cell. 2007;128;9-13. PMID: 17218247 DOI: 10.1016/j.cell.2006.12.018
  • A new partner for the international knockout mouse consortium.
    Collins FS, Finnell RH, Rossant J, Wurst W
    Cell. 2007;129;235. PMID: 17448981 DOI: 10.1016/j.cell.2007.04.007

2006

  • Engineering embryonic stem cells with recombinase systems.
    Schnütgen F, Stewart AF, von Melchner H, Anastassiadis K
    Methods Enzymol. 2006;420;100-36. PMID: 17161696 DOI: 10.1016/S0076-6879(06)20007-7
  • The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse.
    Nord AS, Chang PJ, Conklin BR, Cox AV, Harper CA, Hicks GG, Huang CC, Johns SJ, Kawamoto M, Liu S, Meng EC, Morris JH, Rossant J, Ruiz P, Skarnes WC, Soriano P, Stanford WL, Stryke D, von Melchner H, Wurst W, Yamamura K, Young SG, Babbitt PC, Ferrin TE
    Nucleic Acids Res. 2006;34;D642-8. PMID: 16381950 DOI: 10.1093/nar/gkj097

2005

  • EMPReSS: standardized phenotype screens for functional annotation of the mouse genome.
    Brown SD, Chambon P, de Angelis MH,
    Nat Genet. 2005;37;1155. PMID: 16254554 DOI: 10.1038/ng1105-1155
  • Genomewide production of multipurpose alleles for the functional analysis of the mouse genome.
    Schnütgen F, De-Zolt S, Van Sloun P, Hollatz M, Floss T, Hansen J, Altschmied J, Seisenberger C, Ghyselinck NB, Ruiz P, Chambon P, Wurst W, von Melchner H
    Proc Natl Acad Sci U S A. 2005;102;7221-6. PMID: 15870191 DOI: 10.1073/pnas.0502273102

2004

  • The European dimension for the mouse genome mutagenesis program.
    Auwerx J, Avner P, Baldock R, Ballabio A, Balling R, Barbacid M, Berns A, Bradley A, Brown S, Carmeliet P, Chambon P, Cox R, Davidson D, Davies K, Duboule D, Forejt J, Granucci F, Hastie N, de Angelis MH, Jackson I, Kioussis D, Kollias G, Lathrop M, Lendahl U, Malumbres M, von Melchner H, Müller W, Partanen J, Ricciardi-Castagnoli P, Rigby P, Rosen B, Rosenthal N, Skarnes B, Stewart AF, Thornton J, Tocchini-Valentini G, Wagner E, Wahli W, Wurst W
    Nat Genet. 2004;36;925-7. PMID: 15340424 DOI: 10.1038/ng0904-925
  • A public gene trap resource for mouse functional genomics.
    Skarnes WC, von Melchner H, Wurst W, Hicks G, Nord AS, Cox T, Young SG, Ruiz P, Soriano P, Tessier-Lavigne M, Conklin BR, Stanford WL, Rossant J,
    Nat Genet. 2004;36;543-4. PMID: 15167922 DOI: 10.1038/ng0604-543
  • The knockout mouse project.
    Austin CP, Battey JF, Bradley A, Bucan M, Capecchi M, Collins FS, Dove WF, Duyk G, Dymecki S, Eppig JT, Grieder FB, Heintz N, Hicks G, Insel TR, Joyner A, Koller BH, Lloyd KC, Magnuson T, Moore MW, Nagy A, Pollock JD, Roses AD, Sands AT, Seed B, Skarnes WC, Snoddy J, Soriano P, Stewart DJ, Stewart F, Stillman B, Varmus H, Varticovski L, Verma IM, Vogt TF, von Melchner H, Witkowski J, Woychik RP, Wurst W, Yancopoulos GD, Young SG, Zambrowicz B
    Nat Genet. 2004;36;921-4. PMID: 15340423 DOI: 10.1038/ng0904-921
  • Von Melchner H, Stewart AF. 2004. Engineering of ES cell genomes with recombinase systems.
    In the Handbook of Stem Cells, ed. R Lanza, pp. 609-22: Elsevier Academic Press.

2003

  • A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
    Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P
    Proc Natl Acad Sci U S A. 2003;100;9918-22. PMID: 12904583 DOI: 10.1073/pnas.1633296100

2001

  • Functional analysis of secreted and transmembrane proteins critical to mouse development.
    Mitchell KJ, Pinson KI, Kelly OG, Brennan J, Zupicich J, Scherz P, Leighton PA, Goodrich LV, Lu X, Avery BJ, Tate P, Dill K, Pangilinan E, Wakenight P, Tessier-Lavigne M, Skarnes WC
    Nat Genet. 2001;28;241-9. PMID: 11431694 DOI: 10.1038/90074

2000

  • Gene trapping methods for the identification and functional analysis of cell surface proteins in mice.
    Skarnes WC
    Methods Enzymol. 2000;328;592-615. PMID: 11075368
  • An LDL-receptor-related protein mediates Wnt signalling in mice.
    Pinson KI, Brennan J, Monkley S, Avery BJ, Skarnes WC
    Nature. 2000;407;535-8. PMID: 11029008 DOI: 10.1038/35035124

1997

  • Rapid sequence analysis of gene trap integrations to generate a resource of insertional mutations in mice.
    Townley DJ, Avery BJ, Rosen B, Skarnes WC
    Genome Res. 1997;7;293-8. PMID: 9074932

1995

  • Capturing genes encoding membrane and secreted proteins important for mouse development.
    Skarnes WC, Moss JE, Hurtley SM, Beddington RS
    Proc Natl Acad Sci U S A. 1995;92;6592-6. PMID: 7604039
Last Modified Wed Jan 27 10:25:59 2010 © 2008, EUCOMM Project