Information About EUCOMM

Objectives

• Generation, archiving, and world-wide distribution of up to 13.000 conditional mutations across the mouse genome in mouse embryonic stem (ES) cells
• Mutant ES cells and targeting vectors are distributed by the European Mouse Mutant Cell Repository (EuMMCR)
• Establishment, archiving, and world-wide distribution of first up to 320 mouse mutants from this resource
• Mutant mice will be distributed by the European Mouse Mutant Archive (EMMA)

Mutagenesis Strategies

• Conditional gene trapping - random approach for expressed genes
• Conditional targeted trapping - directed approach, used for expressed genes
• Conditional gene targeting - directed approach, used for non-expressed genes

Networking

• Generation of European mouse functional genomics platform by synergistic integration of EMMA, EUMODIC, EURExpress, FLPFLEX, EMAGE, FunGenES, PRIME and others
• Cornerstone of world-wide mouse mutagenesis effort, collaborating with the Canadian (NorCOMM) and the U.S. (KOMP) programs, member of the International Knockout Mouse Consortium (IKMC)

Societal Benefits

• Improvement of health research
• Speedup of drug development, therapy and diagnosis
• Competitive advantage for pharmaceutical industry

Funding & Structure

• Funded by European Union (FP 6)
• EU funding: up to 13 million Euro
• Integrated Project
• Consortium: 9 Participants from four European countries